ALLOTYPE EXCLUSION IN UNIFORM RABBIT ANTIBODY TO STREPTOCOCCAL CARBOHYDRATE

Kindt , Thomas J.; Todd , Charles W.; Eichmann , Klaus; Krause , Richard M.

doi:10.1084/jem.131.2.343

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Article| February 01 1970

ALLOTYPE EXCLUSION IN UNIFORM RABBIT ANTIBODY TO STREPTOCOCCAL CARBOHYDRATE

Thomas J. Kindt,

Thomas J. Kindt

From the Biology Department, City of Hope Medical Center, Duarte, California 91010, and The Rockefeller University, New York 10021

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Charles W. Todd,

Charles W. Todd

From the Biology Department, City of Hope Medical Center, Duarte, California 91010, and The Rockefeller University, New York 10021

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Klaus Eichmann,

Klaus Eichmann

From the Biology Department, City of Hope Medical Center, Duarte, California 91010, and The Rockefeller University, New York 10021

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Richard M. Krause

From the Biology Department, City of Hope Medical Center, Duarte, California 91010, and The Rockefeller University, New York 10021

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Author and Article Information

Thomas J. Kindt

From the Biology Department, City of Hope Medical Center, Duarte, California 91010, and The Rockefeller University, New York 10021

Charles W. Todd

From the Biology Department, City of Hope Medical Center, Duarte, California 91010, and The Rockefeller University, New York 10021

Klaus Eichmann

From the Biology Department, City of Hope Medical Center, Duarte, California 91010, and The Rockefeller University, New York 10021

Richard M. Krause

From the Biology Department, City of Hope Medical Center, Duarte, California 91010, and The Rockefeller University, New York 10021

Received: September 16 1969

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1970

J Exp Med (1970) 131 (2): 343–354.

https://doi.org/10.1084/jem.131.2.343

Rabbit antibodies to streptococcal polysaccharide are described which show selectivity of expression of the allotypic specificities on both the heavy (H) and light (L) chains. One of these antibodies binds weakly to Sephadex. A purification method based on this binding has yielded antibody completely lacking any group a allotypic marker on its H chains.

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ALLOTYPE EXCLUSION IN UNIFORM RABBIT ANTIBODY TO STREPTOCOCCAL CARBOHYDRATE

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