STUDIES ON ANTIBODY PRODUCTION VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE

O'Brien , Thomas F.; Coons , Albert H.

doi:10.1084/jem.117.6.1063

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Article| June 01 1963

STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE

Thomas F. O'Brien,

Thomas F. O'Brien

From the Department of Bacteriology and Immunology, Harvard Medical School, Boston

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Albert H. Coons

From the Department of Bacteriology and Immunology, Harvard Medical School, Boston

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Author and Article Information

Thomas F. O'Brien

From the Department of Bacteriology and Immunology, Harvard Medical School, Boston

Albert H. Coons

From the Department of Bacteriology and Immunology, Harvard Medical School, Boston

Received: March 03 1963

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1963

J Exp Med (1963) 117 (6): 1063–1074.

https://doi.org/10.1084/jem.117.6.1063

Incorporation of 5-bromodeoxyuridine (BUDR) in the culture medium for the 2nd, 3rd, or 4th day after in vitro antigen stimulation of rabbit popliteal lymph node fragments suppressed the in vitro anamnestic antibody response described previously. Before or after this 3-day period, BUDR had no measurable effect. The results suggest that the antibody response in this in vitro system depends upon cell multiplication during this period.

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STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE

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