Adenosine, but not guanosine, was capable of blocking the inhibitory effect of 5,6-dichloro-1-ß-D-ribofuranosylbenzimidazole (DRB) on influenza virus multiplication in the chorioallantoic membrane in vitro. At virus inhibitory concentrations DRB caused marked inhibition in uptake of adenosine-8-C14 into RNA of uninfected host cells, but it had little effect on uptake of C14-L-alanine into host cell proteins or on cellular oxygen consumption. The activity of DRB in inhibiting multiplication of the DNA-containing adenovirus was similar to its inhibitory activity on multiplication of the RNA-containing influenza virus. These and earlier results are discussed from the point of view of the important role of RNA in the reproduction of DNA-containing viruses.
ON THE ROLE OF RIBONUCLEIC ACID IN ANIMAL VIRUS SYNTHESIS : I. STUDIES WITH 5,6-DICHLORO-1-ß-D-RIBOFURANOSYLBENZIMIDAZOLE
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Search Site
Igor Tamm, Marjorie M. Nemes, Suydam Osterhout; ON THE ROLE OF RIBONUCLEIC ACID IN ANIMAL VIRUS SYNTHESIS : I. STUDIES WITH 5,6-DICHLORO-1-ß-D-RIBOFURANOSYLBENZIMIDAZOLE . J Exp Med 1 March 1960; 111 (3): 339–349. doi: https://doi.org/10.1084/jem.111.3.339
Download citation file: