The intravenous administration to rats of soluble antigen-antibody complexes in antigen excess resulted in acute glomerulonephritis. This occurred with both rabbit antiovalbumin and rabbit anti-BSA systems.
The rats so treated regularly showed proteinuria and elevation of blood urea nitrogen.
These findings are compared with those reported in rats injected with anti-kidney serum.
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©Copyright 1960, by The Rockefeller Institute
1960
