Eight young rhesus monkeys were fed a purified diet devoid of vitamin E. After from 6 to 13 months of feeding, all the animals developed signs of vitamin E deficiency. The signs of vitamin E deficiency in the monkey include muscular dystrophy, elevated excretion of creatine, allantoin, and free amino acids and decreased excretion of creatinine. The vitamin E-deficient monkeys all developed anemia and granulocytosis. Anemia was the first sign of vitamin E deficiency which was observed. All of these signs of vitamin E deficiency were reversed by treatment with α-tocopherol.
VITAMIN E DEFICIENCY IN THE MONKEY : I. MUSCULAR DYSTROPHY, HEMATOLOGIC CHANGES, AND THE EXCRETION OF URINARY NITROGENOUS CONSTITUENTS
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James S. Dinning, Paul L. Day; VITAMIN E DEFICIENCY IN THE MONKEY : I. MUSCULAR DYSTROPHY, HEMATOLOGIC CHANGES, AND THE EXCRETION OF URINARY NITROGENOUS CONSTITUENTS . J Exp Med 1 May 1957; 105 (5): 395–402. doi: https://doi.org/10.1084/jem.105.5.395
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