The osmotic activity of liver tissue and of kidney cortex tested within 10 minutes after immersion in solutions of sodium chloride has been increased by procedures which introduce sodium chloride, urea or creatinin into the body in excess of its elimination.

A substance formed by cell metabolism, namely urea, can increase the osmotic activity of liver and of kidney cells.

The amino acids, glycine and arginine, under similar conditions have not increased the osmotic activity of liver or of kidney cortex.

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