The anti-inflammatory action of cortisone upon the acute cellular response to thermal injury has been systematically studied in the rabbit ear chamber. The hormone has been shown to suppress the reaction of acute inflammation in its earliest recognizable phase; i.e., that involving vasodilatation and the adherence of leucocytes to the vascular endothelium. Evidence has been presented that the anti-inflammatory effect of the hormone cannot be explained on the basis of its vasoconstrictive properties alone. The experimental observations support the hypothesis that cortisone exerts a direct protective action upon endothelial cells and leucocytes, and that in so doing, it renders them refractory to the tissue products which initiate inflammation.
Article|
December 01 1955
STUDIES ON THE PATHOGENESIS OF ACUTE INFLAMMATION : II. THE ACTION OF CORTISONE ON THE INFLAMMATORY RESPONSE TO THERMAL INJURY
Fred Allison, Jr.,
Fred Allison, Jr.
From the Departments of Medicine and Preventive Medicine, Washington University School of Medicine, and the Barnes and Wohl Hospitals, St. Louis
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Mary Ruth Smith,
Mary Ruth Smith
From the Departments of Medicine and Preventive Medicine, Washington University School of Medicine, and the Barnes and Wohl Hospitals, St. Louis
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W. Barry Wood, Jr.
W. Barry Wood, Jr.
From the Departments of Medicine and Preventive Medicine, Washington University School of Medicine, and the Barnes and Wohl Hospitals, St. Louis
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Fred Allison, Jr.
From the Departments of Medicine and Preventive Medicine, Washington University School of Medicine, and the Barnes and Wohl Hospitals, St. Louis
Mary Ruth Smith
From the Departments of Medicine and Preventive Medicine, Washington University School of Medicine, and the Barnes and Wohl Hospitals, St. Louis
W. Barry Wood, Jr.
From the Departments of Medicine and Preventive Medicine, Washington University School of Medicine, and the Barnes and Wohl Hospitals, St. Louis
Received:
July 26 1955
Online Issn: 1540-9538
Print Issn: 0022-1007
Copyright, 1955, by The Rockefeller Institute for Medical Research New York
1955
J Exp Med (1955) 102 (6): 669–676.
Article history
Received:
July 26 1955
Citation
Fred Allison, Mary Ruth Smith, W. Barry Wood; STUDIES ON THE PATHOGENESIS OF ACUTE INFLAMMATION : II. THE ACTION OF CORTISONE ON THE INFLAMMATORY RESPONSE TO THERMAL INJURY . J Exp Med 1 December 1955; 102 (6): 669–676. doi: https://doi.org/10.1084/jem.102.6.669
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