In mice affected with equine encephalomyelitis, the first pathological disturbance in infant animals is an inflammatory reaction, which is usually less pronounced in adult animals. A characteristic type of parenchymal damage appears to be independent of the inflammation. In such foci of injury there is initially a vacuolation of intercellular tissue. Neurones in such areas are at first intact, later show cytoplasmic changes, and finally nuclear alterations. Complete disintegration of tissue and all its elements may be the end result.

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