Experiments are described which confirm the observation of Gonzalez and Armangué that heterogenetic extracts can be made antigenic by adsorption to inorganic materials. With fractions of the original extracts from which a part of inactive material had been removed no such enhancement was observed, whereas with foreign protein an activation was still possible. Carbohydrate preparations behaved similarly in that purification, perhaps loss of protein, was accompanied by a distinct decrease in antigenicity after adsorption. The activity of a but slightly antigenic heteroalbumose preparation was markedly increased after adsorption to charcoal and alum. The most reasonable explanation for the effects observed by Gonzalez and Armangué, and Zozaya, seems to be that a preexisting antigenic capacity has been enhanced by the use of adsorbents. The experiments reported here support the view that these effects are influenced significantly by the presence of substances other than those of a specific nature.
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April 01 1934
ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS
John Jacobs
John Jacobs
From the Laboratories of The Rockefeller Institute for Medical Research
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John Jacobs
From the Laboratories of The Rockefeller Institute for Medical Research
Received:
December 18 1933
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1934, by The Rockefeller Institute for Medical Research New York
1934
J Exp Med (1934) 59 (4): 479–490.
Article history
Received:
December 18 1933
Citation
John Jacobs; ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS . J Exp Med 1 April 1934; 59 (4): 479–490. doi: https://doi.org/10.1084/jem.59.4.479
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