Vol. 213, No. 7, June 27, 2016. https://doi.org/10.1084/jem.20151110

The authors regret that in the original version of their paper, two values for patient 2 in Table 2 were incorrect. The corrected values are red in the table below.

Table 2.

Immune phenotype of patient 1, 2, and 3

 Patient 1 (6 yr)  Patient 2 (8 yr)  Patient 3 (2 yr)  
Relative counts  Reference values  Absolute  Reference values  Relative counts  Reference values  Absolute  Reference values  Relative counts  Reference values  Absolute  Reference values  
Lymphocytes a    1,855  1,800–5,000    900  1,800–5,000    4,950  2,800–6,400  
B cells a  2.0  8.5–20.2  37  296–784  3.8  8.5–20.2  34  296–784  29.9  17.3–30.0  1,480  686–1,732  
CD4 a  4.0  26.5–41.4  74  641–1,453  24.5  26.5–41.4  220  641–1,453  6.4  28.1–43.2  317  925–2,477  
CD8 b  45.0  13–47  834  200–1,700  38.3  13–47  345  200–1,700  4.5  9–49  223  200–1,800  
NK cells b  6.0  2–31  114  70–590  1.7  2–31  16  70–590  0.9  2–25  45  61–510  
B cell subpopulations a  ND   ND       ND   ND   
Transitional      21.1  3.4–9.0  5  13–63      
Naive      68.7  47.8–69.8  23  154–413      
IgM memory      3.5  6.3–22  2  24–135      
IgM only      0.7  2–11.8  1  7–65      
IgA cs memory      0  1.1–6.1  0  5–35      
IgG cs memory      0  2.7–14  0  13–74      
CD21low      6.3         
CD4 subpopulations a  ND   ND       ND   ND   
RTEc      24.4  61–84.2  1       
Naive      2.4  55.6–75.8  5  375–1,096      
CD45R0      97.5  24–43        
T reg cells      2.0  2.3–7.7  5  18–86      
cTFHd      35.0  18.4–29.9  112  51–218      
Th2+Th17-like cTFHd      29.4  39.9–66.1  33  26–85      
CD8 subpopulations b  ND   ND       ND   ND   
Naive      0.3  16–100  1  42–1,300      
Central memory      2.4  1–6  8  6–43      
Effector memory      65.9  5–100  227  45–410      
Terminally differentiated      1.6  15–41  6  57–340      
γδ T cells e  ND   ND   37.2  <10  282  12–175  72  <10  2,217  12–175  
DN T cells e  51     38     72     
NK T cells e  ND   ND   0.005  >0.01  ND   ND   ND   
 Patient 1 (6 yr)  Patient 2 (8 yr)  Patient 3 (2 yr)  
Relative counts  Reference values  Absolute  Reference values  Relative counts  Reference values  Absolute  Reference values  Relative counts  Reference values  Absolute  Reference values  
Lymphocytes a    1,855  1,800–5,000    900  1,800–5,000    4,950  2,800–6,400  
B cells a  2.0  8.5–20.2  37  296–784  3.8  8.5–20.2  34  296–784  29.9  17.3–30.0  1,480  686–1,732  
CD4 a  4.0  26.5–41.4  74  641–1,453  24.5  26.5–41.4  220  641–1,453  6.4  28.1–43.2  317  925–2,477  
CD8 b  45.0  13–47  834  200–1,700  38.3  13–47  345  200–1,700  4.5  9–49  223  200–1,800  
NK cells b  6.0  2–31  114  70–590  1.7  2–31  16  70–590  0.9  2–25  45  61–510  
B cell subpopulations a  ND   ND       ND   ND   
Transitional      21.1  3.4–9.0  5  13–63      
Naive      68.7  47.8–69.8  23  154–413      
IgM memory      3.5  6.3–22  2  24–135      
IgM only      0.7  2–11.8  1  7–65      
IgA cs memory      0  1.1–6.1  0  5–35      
IgG cs memory      0  2.7–14  0  13–74      
CD21low      6.3         
CD4 subpopulations a  ND   ND       ND   ND   
RTEc      24.4  61–84.2  1       
Naive      2.4  55.6–75.8  5  375–1,096      
CD45R0      97.5  24–43        
T reg cells      2.0  2.3–7.7  5  18–86      
cTFHd      35.0  18.4–29.9  112  51–218      
Th2+Th17-like cTFHd      29.4  39.9–66.1  33  26–85      
CD8 subpopulations b  ND   ND       ND   ND   
Naive      0.3  16–100  1  42–1,300      
Central memory      2.4  1–6  8  6–43      
Effector memory      65.9  5–100  227  45–410      
Terminally differentiated      1.6  15–41  6  57–340      
γδ T cells e  ND   ND   37.2  <10  282  12–175  72  <10  2,217  12–175  
DN T cells e  51     38     72     
NK T cells e  ND   ND   0.005  >0.01  ND   ND   ND   

Relative counts are shown as a percentage of parental population. Absolute numbers refer to cells/microliter. CD4 T cell subpopulations: recent thymic emigrants (RTEs), CD31+ of CD45RA+ CD4 T cells; T reg cells, CD127− CD25hi of CD45RA− CD4 T cells; circulating T follicular helper–like cell (cTFH), CXCR5+ of CD45RA− CD4 T cells; Th2/Th17-like cTFH, CXCR3− of CXCR5+ CD45RA− CD4 T cells. CD8 T cell populations: naive, CCR7+ CD45RA+ CD27+; terminally differentiated, CCR7− CD45RA+ CD27−; central memory, CCR7+ CD45RA− CD27+; effector memory, CCR7− CD45RA− CD27−. Double-negative (DN) T cells, CD4−/CD8− of CD3 T cells. NK T cells, Vα24 Vβ11 CD3 T cells. cs, class switched.

a

van Gent et al., 2009.

b

Schatorjé et al., 2012.

c

Percentage of naive CD4 T cells.

d

Internal reference value.

e

Internal reference value of CD3 T cells.

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