Previous studies implicate the nonreceptor protein tyrosine kinase (PTK) p59fyn in the propagation of signals from the B cell antigen receptor. To elucidate the functions of this kinase, we examined B cell responsiveness in mice engineered to lack the hematopoietic isoform of p59fyn. Remarkably, antigen receptor signaling was only modestly defective in fynTnull B cells. In contrast, signaling from the interleukin (IL)-5 receptor which ordinarily provides a comitogenic stimulus with antiimmunoglobulin, was completely blocked. Our results document the importance of p59fynT in IL-5 responses in B cells, and they support a general model for cytokine receptor signal transduction involving the simultaneous recruitment of at least three families of PTK.
Involvement of p59fynT in interleukin-5 receptor signaling.
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M W Appleby, J D Kerner, S Chien, C R Maliszewski, S Bondada, R M Perlmutter, S ] Bondadaa S [corrected to Bondada; Involvement of p59fynT in interleukin-5 receptor signaling.. J Exp Med 1 September 1995; 182 (3): 811–820. doi: https://doi.org/10.1084/jem.182.3.811
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