The tal-1 proto-oncogene encodes a helix-loop-helix DNA-binding protein that has been implicated in the formation of T cell acute lymphoblastic leukemia (T-ALL). Patients with T-ALL harbor structural rearrangements of tal-1 that result from either local DNA deletion or t(1;14)(p34;q11) chromosome translocation. By analyzing t(1;14)(p34;q11) chromosomes from a series of patients, we have now identified a discrete region of tal-1 wherein most of the translocation breakpoints occur. Moreover, mapping of tal-1 genomic DNA revealed that coding exons are situated on both sides of the t(1;14)(p34;q11) major breakpoint region. Hence, the translocated allele of tal-1 is truncated in a manner that reduces its amino acid coding potential.
Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.
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Q Chen, C Y Yang, J T Tsan, Y Xia, A H Ragab, S C Peiper, A Carroll, R Baer; Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.. J Exp Med 1 November 1990; 172 (5): 1403–1408. doi: https://doi.org/10.1084/jem.172.5.1403
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