A decrease in thrombocyte count was observed in (NZW x BXSB)F1 (W/B F1) mice at the age of greater than 5 mo, whereas megakaryocyte counts were found to increase in such mice. FACS analyses revealed the presence of both platelet-associated antibodies (PAA) and circulating antiplatelet antibodies. There is a correlation between the presence of these antibodies and the degree of thrombocytopenia. The transplantation of normal bone marrow cells from BALB/c nu/nu mice to W/B F1 mice was found to have preventative and curative effects on thrombocytopenia; the mice showed normal platelet counts and no evidence of circulating antiplatelet antibodies. These results indicate that thrombocytopenia in W/B F1 mice is due to the presence of antibodies to platelets. We therefore think that W/B F1 mice serve as a useful animal model of idiopathic thrombocytopenic purpura (ITP) not only for elucidating the mechanism of the development of antiplatelet antibodies, but also for characterizing autoantibodies to platelets.
(NZW x BXSB)F1 mouse. A new animal model of idiopathic thrombocytopenic purpura.
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N Oyaizu, R Yasumizu, M Miyama-Inaba, S Nomura, H Yoshida, S Miyawaki, Y Shibata, S Mitsuoka, K Yasunaga, S Morii; (NZW x BXSB)F1 mouse. A new animal model of idiopathic thrombocytopenic purpura.. J Exp Med 1 June 1988; 167 (6): 2017–2022. doi: https://doi.org/10.1084/jem.167.6.2017
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