THE IMMUNOGENICITY OF HUMAN HL-A HAPLOTYPES AS MEASURED BY SKIN GRAFT SURVIVAL TIMES AND MIXED LEUKOCYTE REACTIONS

Seigler , H. F.; Ward , F. E.; Amos , D. B.; Phaup , M. B.; Stickel , D. L.

doi:10.1084/jem.133.3.411

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Article| March 01 1971

THE IMMUNOGENICITY OF HUMAN HL-A HAPLOTYPES AS MEASURED BY SKIN GRAFT SURVIVAL TIMES AND MIXED LEUKOCYTE REACTIONS

H. F. Seigler,

H. F. Seigler

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

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F. E. Ward,

F. E. Ward

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

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D. B. Amos,

D. B. Amos

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

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M. B. Phaup,

M. B. Phaup

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

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D. L. Stickel

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

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Author and Article Information

H. F. Seigler

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

F. E. Ward

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

D. B. Amos

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

M. B. Phaup

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

D. L. Stickel

From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

Received: September 24 1970

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1971

J Exp Med (1971) 133 (3): 411–423.

https://doi.org/10.1084/jem.133.3.411

The immunogenicity of the haplotypes in 30 families was measured by survival of skin grafts between selected paired family members. These families were genotyped for HL-A using 57 selected cytotoxic alloantisera defining HL-A 1–12 as well as other nondefined specificities. Mixed leukocyte reactions were also studied in this series and the correlations between the mixed leukocyte reactions with skin graft survival times, individual HL-A specificities, and the number of incompatible HL-A alleles are reported. Comments concerning the interpretation and quantitation of the mixed leukocyte reactions are discussed.

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1971

THE IMMUNOGENICITY OF HUMAN HL-A HAPLOTYPES AS MEASURED BY SKIN GRAFT SURVIVAL TIMES AND MIXED LEUKOCYTE REACTIONS

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