MECHANISM OF PROTEINURIA III. A COMPARISON OF THE FUNCTIONAL AND STRUCTURAL ASPECTS OF THE EFFECTS OF CERTAIN INTRAPERITONEALLY ADMINISTERED PROTEINS ON HEMOGLOBIN EXCRETION IN THE RAT

Lippman , Richard W.; Ureen , Helen J.; Oliver , Jean

doi:10.1084/jem.93.4.325

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Article| April 01 1951

MECHANISM OF PROTEINURIA : III. A COMPARISON OF THE FUNCTIONAL AND STRUCTURAL ASPECTS OF THE EFFECTS OF CERTAIN INTRAPERITONEALLY ADMINISTERED PROTEINS ON HEMOGLOBIN EXCRETION IN THE RAT

Richard W. Lippman,

Richard W. Lippman

From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles, and the Hoagland Laboratory, the Department of Pathology of the College of Medicine at the State University Medical Center, New York

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Helen J. Ureen,

Helen J. Ureen

From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles, and the Hoagland Laboratory, the Department of Pathology of the College of Medicine at the State University Medical Center, New York

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Jean Oliver

From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles, and the Hoagland Laboratory, the Department of Pathology of the College of Medicine at the State University Medical Center, New York

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Author and Article Information

Richard W. Lippman

From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles, and the Hoagland Laboratory, the Department of Pathology of the College of Medicine at the State University Medical Center, New York

Helen J. Ureen

From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles, and the Hoagland Laboratory, the Department of Pathology of the College of Medicine at the State University Medical Center, New York

Jean Oliver

From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles, and the Hoagland Laboratory, the Department of Pathology of the College of Medicine at the State University Medical Center, New York

Received: November 21 1950

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1951, by The Rockefeller Institute for Medical Research New York

1951

J Exp Med (1951) 93 (4): 325–336.

https://doi.org/10.1084/jem.93.4.325

Intraperitoneal administration of bovine albumin sharply increases glomerular permeability to hemoglobin in the rat kidney. In addition, bovine albumin "saturates" the tubular absorption mechanism and inhibits the tubular absorption of subsequently administered hemoglobin. Egg white, ovalbumin, and ovomucoid, in contrast, do not produce significant changes in glomerular permeability to hemoglobin or in the tubular absorption of hemoglobin. These effects have been demonstrated both by physiologic measurements and by the morphologic demonstration of the absorbed proteins.

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Copyright, 1951, by The Rockefeller Institute for Medical Research New York

1951

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MECHANISM OF PROTEINURIA : III. A COMPARISON OF THE FUNCTIONAL AND STRUCTURAL ASPECTS OF THE EFFECTS OF CERTAIN INTRAPERITONEALLY ADMINISTERED PROTEINS ON HEMOGLOBIN EXCRETION IN THE RAT

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