The rates of elution from RBC of the Lee and PR8 strains of influenza virus were studied by means of a step-wise elution technique. By means of a single treatment with lanthanum acetate or irradiation with ultraviolet and subsequent passage in chick embryos, it was possible to alter the elution rate of the Lee strain so that it was similar to that of the PR8 strain. This alteration proved to be persistent on serial passage in the absence of the agent which caused it. As far as was determined, the elution rate of the virus appeared to be the only property which was altered. The phenomenon can be most readily understood on the assumption that the difference in elution rates of the two strains is due to a heterogeneous population of virus particles in the Lee strain with respect to elution rate.
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1 October 1948
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October 01 1948
THE PRODUCTION OF A PERSISTENT ALTERATION IN INFLUENZA VIRUS BY LANTHANUM OR ULTRAVIOLET IRRADIATION
Sven E. Björkman,
Sven E. Björkman
From the Hospital of The Rockefeller Institute for Medical Research
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Frank L. Horsfall, Jr.
Frank L. Horsfall, Jr.
From the Hospital of The Rockefeller Institute for Medical Research
Search for other works by this author on:
Sven E. Björkman
From the Hospital of The Rockefeller Institute for Medical Research
Frank L. Horsfall, Jr.
From the Hospital of The Rockefeller Institute for Medical Research
Received:
July 12 1948
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1948, by The Rockefeller Institute for Medical Research New York
1948
J Exp Med (1948) 88 (4): 445–461.
Article history
Received:
July 12 1948
Citation
Sven E. Björkman, Frank L. Horsfall; THE PRODUCTION OF A PERSISTENT ALTERATION IN INFLUENZA VIRUS BY LANTHANUM OR ULTRAVIOLET IRRADIATION . J Exp Med 1 October 1948; 88 (4): 445–461. doi: https://doi.org/10.1084/jem.88.4.445
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