THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

Kabat , Elvin A.; Wolf , Abner; Bezer , Ada E.

doi:10.1084/jem.85.1.117

Article navigation

Article| January 01 1947

THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

Elvin A. Kabat,

Elvin A. Kabat

From the Departments of Neurology and Pathology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, New York

Search for other works by this author on:

This Site

PubMed

Google Scholar

Abner Wolf,

Abner Wolf

From the Departments of Neurology and Pathology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, New York

Search for other works by this author on:

This Site

PubMed

Google Scholar

Ada E. Bezer

From the Departments of Neurology and Pathology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, New York

Search for other works by this author on:

This Site

PubMed

Google Scholar

Author and Article Information

Elvin A. Kabat

From the Departments of Neurology and Pathology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, New York

Abner Wolf

From the Departments of Neurology and Pathology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, New York

Ada E. Bezer

From the Departments of Neurology and Pathology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, New York

Received: July 31 1946

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1947, by The Rockefeller Institute for Medical Research New York

1947

J Exp Med (1947) 85 (1): 117–130.

https://doi.org/10.1084/jem.85.1.117

1. A picture resembling acute disseminated encephalomyelitis in the human being has been regularly and rapidly produced in rhesus monkeys by injection of emulsions of adult rabbit and monkey brain administered with adjuvants.

2. No lesions of the central nervous system resulted from injection of similar emulsions of fetal rabbit brain or adult rabbit lung.

3. A description of the gross and histological findings in the central nervous system is given and compared with features of human demyelinating disease.

4. The experimental findings are in accord with the hypothesis that antibody to the injected brain emulsion reacts with the tissues of the nervous system of the animal to produce the pathological changes.

This content is only available as a PDF.

Copyright, 1947, by The Rockefeller Institute for Medical Research New York

1947

You do not currently have access to this content.

Don't already have an account? Register

You could not be signed in. Please check your email address / username and password and try again.

THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

Sign in

Client Account

Sign in via your Institution

Suggested Content

Email alerts

This Feature Is Available To Subscribers Only