CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION VII. A QUANTITATIVE STUDY OF THE TYPE SPECIFIC AND GROUP SPECIFIC ANTIBODIES IN ANTIMENINGOCOCCAL SERA OF VARIOUS SPECIES AND THEIR RELATION TO MOUSE PROTECTION

Kabat , Elvin A.; Miller , C. Phillip; Kaiser , Hilda; Foster , Alice Z.

doi:10.1084/jem.81.1.1

Article navigation

Article| January 01 1945

CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION : VII. A QUANTITATIVE STUDY OF THE TYPE SPECIFIC AND GROUP SPECIFIC ANTIBODIES IN ANTIMENINGOCOCCAL SERA OF VARIOUS SPECIES AND THEIR RELATION TO MOUSE PROTECTION

Elvin A. Kabat,

Elvin A. Kabat

From the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, the Neurological Institute of New York, and the Department of Medicine, The University of Chicago

Search for other works by this author on:

This Site

PubMed

Google Scholar

C. Phillip Miller,

C. Phillip Miller

From the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, the Neurological Institute of New York, and the Department of Medicine, The University of Chicago

Search for other works by this author on:

This Site

PubMed

Google Scholar

Hilda Kaiser,

Hilda Kaiser

From the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, the Neurological Institute of New York, and the Department of Medicine, The University of Chicago

Search for other works by this author on:

This Site

PubMed

Google Scholar

Alice Z. Foster

From the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, the Neurological Institute of New York, and the Department of Medicine, The University of Chicago

Search for other works by this author on:

This Site

PubMed

Google Scholar

Author and Article Information

Elvin A. Kabat

From the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, the Neurological Institute of New York, and the Department of Medicine, The University of Chicago

C. Phillip Miller

From the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, the Neurological Institute of New York, and the Department of Medicine, The University of Chicago

Hilda Kaiser

From the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, the Neurological Institute of New York, and the Department of Medicine, The University of Chicago

Alice Z. Foster

From the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, the Neurological Institute of New York, and the Department of Medicine, The University of Chicago

Received: May 12 1944

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1945, by The Rockefeller Institute for Medical Research New York

1945

J Exp Med (1945) 81 (1): 1–8.

https://doi.org/10.1084/jem.81.1.1

1. The quantitative method for the estimation of agglutinins has been applied to antimeningococcal horse, rabbit, and chicken sera and to the sera of humans convalescing from meningococcus meningitis. The type-specific and group-specific agglutinin N can be measured, using homologous and heterologous suspensions of meningococci.

2. Type I horse, rabbit, and chicken antimeningococcal sera contain considerable amounts of antibody which cannot be removed either by Type II meningococcus suspension or by preparations of the Type I specific polysaccharide. This residual type-specific antibody has marked potency in protecting mice against subsequent infection with meningococci.

3. Most human convalescent sera contain group-specific antibody. Small amounts of protective antibody and of antipolysaccharide are also formed.

4. Type I antisera absorbed with Type I polysaccharide and with Type II meningococci could be used as a guide in the purification of this new antigen.

This content is only available as a PDF.

Copyright, 1945, by The Rockefeller Institute for Medical Research New York

1945

You do not currently have access to this content.

Don't already have an account? Register

You could not be signed in. Please check your email address / username and password and try again.

CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION : VII. A QUANTITATIVE STUDY OF THE TYPE SPECIFIC AND GROUP SPECIFIC ANTIBODIES IN ANTIMENINGOCOCCAL SERA OF VARIOUS SPECIES AND THEIR RELATION TO MOUSE PROTECTION

Sign in

Client Account

Sign in via your Institution

Suggested Content

Email alerts

This Feature Is Available To Subscribers Only