QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN II. THE INTERRELATION OF COMPLEMENT WITH ANTIGEN-ANTIBODY COMPOUNDS AND WITH SENSITIZED RED CELLS

Heidelberger , Michael; Weil , Alfred J.; Treffers , Henry P.

doi:10.1084/jem.73.6.695

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Article| June 01 1941

QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : II. THE INTERRELATION OF COMPLEMENT WITH ANTIGEN-ANTIBODY COMPOUNDS AND WITH SENSITIZED RED CELLS

Michael Heidelberger,

Michael Heidelberger

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

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Alfred J. Weil,

Alfred J. Weil

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

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Henry P. Treffers

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

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Author and Article Information

Michael Heidelberger

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

Alfred J. Weil

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

Henry P. Treffers

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

Received: March 21 1941

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1941, by The Rockefeller Institute for Medical Research New York

1941

J Exp Med (1941) 73 (6): 695–709.

https://doi.org/10.1084/jem.73.6.695

1. The molecular quantities of hemolysin and complement combining component or components (C'1) involved in hemolysis have been calculated on the basis of new, quantitative, absolute methods of analysis.

2. Molecular combining ratios between antigen, antibody, and C'1 have been established.

3. The data are shown to be in accord with the theory of combination of multivalent antigen with multivalent antibody.

4. The fixation of complement by antigen-antibody combination is qualitatively and quantitatively accounted for on this basis.

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Copyright, 1941, by The Rockefeller Institute for Medical Research New York

1941

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QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : II. THE INTERRELATION OF COMPLEMENT WITH ANTIGEN-ANTIBODY COMPOUNDS AND WITH SENSITIZED RED CELLS

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