QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION EFFECT OF SALTS ON THE REACTION

Heidelberger , Michael; Kendall , Forrest E.; Teorell , Torsten

doi:10.1084/jem.63.6.819

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Article| June 01 1936

QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : EFFECT OF SALTS ON THE REACTION

Michael Heidelberger,

Michael Heidelberger

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

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Forrest E. Kendall,

Forrest E. Kendall

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

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Torsten Teorell

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

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Author and Article Information

Michael Heidelberger

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

Forrest E. Kendall

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

Torsten Teorell

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

Received: March 19 1936

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1936, by The Rockefeller Institute for Medical Research New York

1936

J Exp Med (1936) 63 (6): 819–826.

https://doi.org/10.1084/jem.63.6.819

1. A quantitative study has been made of the effect on the precipitin reaction between the specific polysaccharide of Type III pneumococcus and the homologous antibody of salt concentrations ranging from O.1 M to 1.79 M, including the effect of ions of higher valence.

2. Within these limits, observed decreases in precipitated antibody with increasing salt concentration appear to be due to a decrease in the amount of antibody combined with the S III, rather than to an increase in solubility of the S III-antibody compounds.

3. The egg albumin-antibody reaction is far less sensitive to changes in salt concentration than is the S III-antibody reaction.

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Copyright, 1936, by The Rockefeller Institute for Medical Research New York

1936

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