THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN

Evans , Herbert M.; Simpson , Miriam E.; Austin , Paul R.

doi:10.1084/jem.57.6.897

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Article| June 01 1933

THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN

Herbert M. Evans,

Herbert M. Evans

From the Laboratories of The Rockefeller Institute of Medical Research, New York, and the University of California, Berkeley

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Miriam E. Simpson,

Miriam E. Simpson

From the Laboratories of The Rockefeller Institute of Medical Research, New York, and the University of California, Berkeley

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Paul R. Austin

From the Laboratories of The Rockefeller Institute of Medical Research, New York, and the University of California, Berkeley

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Author and Article Information

Herbert M. Evans

From the Laboratories of The Rockefeller Institute of Medical Research, New York, and the University of California, Berkeley

Miriam E. Simpson

From the Laboratories of The Rockefeller Institute of Medical Research, New York, and the University of California, Berkeley

Paul R. Austin

From the Laboratories of The Rockefeller Institute of Medical Research, New York, and the University of California, Berkeley

Received: March 22 1933

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1933, by The Rockefeller Institute for Medical Research New York

1933

J Exp Med (1933) 57 (6): 897–906.

https://doi.org/10.1084/jem.57.6.897

The increased gonadotropic effect obtained by combining prolan with hypophyseal extracts can be secured equally well by the use of preparations which contain high amounts of the growth or of the gonad-stimulating hormone.

In hypophyseal extracts containing the growth hormone, the synergistic effects do not parallel the content of growth-promoting substance.

Similarly, in hypophyseal extracts containing the gonad-stimulating hormone, the synergistic effects do not parallel the content in the gonadotropic factor.

The hypophyseal substance involved has been prepared sufficiently free of the growth and gonad-stimulating hormones to make it inadmissible to consider either of these substances as responsible for the reaction.

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Copyright, 1933, by The Rockefeller Institute for Medical Research New York

1933

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