STUDIES ON MOUSE LEUKEMIA VII. THE RELATION OF CELL DEATH TO THE POTENCY OF INOCULATED CELL SUSPENSIONS

Richter , Maurice N.; MacDowell , E. C.

doi:10.1084/jem.57.1.1

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Article| January 01 1933

STUDIES ON MOUSE LEUKEMIA : VII. THE RELATION OF CELL DEATH TO THE POTENCY OF INOCULATED CELL SUSPENSIONS

Maurice N. Richter,

Maurice N. Richter

From the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, and the Department of Genetics, Carnegie Institution of Washington, Cold Spring Harbor

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E. C. MacDowell

From the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, and the Department of Genetics, Carnegie Institution of Washington, Cold Spring Harbor

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Author and Article Information

Maurice N. Richter

From the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, and the Department of Genetics, Carnegie Institution of Washington, Cold Spring Harbor

E. C. MacDowell

From the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, and the Department of Genetics, Carnegie Institution of Washington, Cold Spring Harbor

Received: July 31 1932

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1933, by The Rockefeller Institute for Medical Research New York

1933

J Exp Med (1933) 57 (1): 1–20.

https://doi.org/10.1084/jem.57.1.1

The effect of heat, hypo- and hypertonic salt solutions, glycerin, desiccation, and mechanical injury was studied on leukemic lymphoid cells of the mouse, and the leukemia-transmitting property of cell suspensions (hypothetical transmitting agent) in vitro.

The results indicate that leukemia has not been transmitted by inoculation without the introduction of living cells. The interval between inoculation and death bears an inverse relationship to the number of living cells inoculated.

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Copyright, 1933, by The Rockefeller Institute for Medical Research New York

1933

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