In normal cultures, the transformation of monocytes into fibroblasts generally occurred when cells became packed together through some mechanical factors that prevented their free migration and determined their accumulation. Various modifications of the medium, the addition of dead tissue, and of trypsin or the products of trypsin digestion, failed to bring about the transformation. The inoculation af cultures of monocytes with filtered extract of Rous sarcoma frequently determined the appearance of fibroblasts. The first change undergone by the monocytes cultivated in vitro was a large increase in their size. Later, the giant monocytes became transformed into cells that did not differ essentially from those that grow from a fragment of adult connective tissue.
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1 April 1926
Article|
April 01 1926
THE TRANSFORMATION OF MONOCYTES INTO FIBROBLASTS THROUGH THE ACTION OF ROUS VIRUS
Alexis Carrel,
Alexis Carrel
From the Laboratories of The Rockefeller Institute for Medical Research.
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Albert H. Ebeling
Albert H. Ebeling
From the Laboratories of The Rockefeller Institute for Medical Research.
Search for other works by this author on:
Alexis Carrel
From the Laboratories of The Rockefeller Institute for Medical Research.
Albert H. Ebeling
From the Laboratories of The Rockefeller Institute for Medical Research.
Received:
January 18 1926
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1926, by The Rockefeller Institute for Medical Research New York
1926
J Exp Med (1926) 43 (4): 461–468.
Article history
Received:
January 18 1926
Citation
Alexis Carrel, Albert H. Ebeling; THE TRANSFORMATION OF MONOCYTES INTO FIBROBLASTS THROUGH THE ACTION OF ROUS VIRUS . J Exp Med 1 April 1926; 43 (4): 461–468. doi: https://doi.org/10.1084/jem.43.4.461
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