ST2, the receptor for the alarmin IL-33, is expressed by a subset of regulatory T (T reg) cells residing in nonlymphoid tissues, and these cells can potently expand upon provision of exogenous IL-33. Whether the accumulation and residence of T reg cells in tissues requires their cell-intrinsic expression of and signaling by ST2, or whether indirect IL-33 signaling acting on other cells suffices, has been a matter of contention. Here, we report that ST2 expression on T reg cells is largely dispensable for their accumulation and residence in nonlymphoid organs, including the visceral adipose tissue (VAT), even though cell-intrinsic sensing of IL-33 promotes type 2 cytokine production by VAT-residing T reg cells. In addition, we uncovered a novel ST2-dependent role for T reg cells in limiting the size of IL-17A–producing γδT cells in the CNS in a mouse model of neuroinflammation, experimental autoimmune encephalomyelitis (EAE). Finally, ST2 deficiency limited to T reg cells led to disease exacerbation in EAE.
T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation
Disclosures: A.Y. Rudensky reported personal fees from Sonoma Biotherapeutics outside the submitted work. No other disclosures were reported.
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Saskia Hemmers, Michail Schizas, Alexander Y. Rudensky; T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation. J Exp Med 1 February 2021; 218 (2): e20201234. doi: https://doi.org/10.1084/jem.20201234
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