Alzheimer’s disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin of these cells has been controversial and is of therapeutic importance. Here, we genetically labeled different myeloid populations and unequivocally demonstrated that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia, with no contribution from circulating peripheral monocytes.
Plaque-associated myeloid cells derive from resident microglia in an Alzheimer’s disease model
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Erin G. Reed-Geaghan, Andrew L. Croxford, Burkhard Becher, Gary E. Landreth; Plaque-associated myeloid cells derive from resident microglia in an Alzheimer’s disease model. J Exp Med 6 April 2020; 217 (4): e20191374. doi: https://doi.org/10.1084/jem.20191374
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