Drugs that collapse the tumor vasculature by increasing the leakiness of tumor blood vessels are a new breed of chemotherapeutic agents, but how they worked was unknown. Now, Roberts et al. (page 1559) have determined the pathway and targets of one such vasculature-disrupting agent (VDA). They find that this drug does more than just increase leakiness.
The VDA called DMXAA works well against several types of human cancers and is currently in phase II clinical trials. But there are no clues from clinical studies to explain why this drug has succeeded where others have failed.
Experiments in mice have hinted at its downstream targets: DMXAA prods mouse macrophages to secrete interferon (IFN)-β and other cytokines that promote vessel permeability. IFN-β is also induced by activation of certain pattern recognition receptors (PRRs), such as the Toll-like receptors and the RNA helicases. But Roberts et al....
