TNF (green) stimulates dendritic cells (red) that cause psoriasis-like lesions (top). Lesions can be relieved by a TNF blocker (bottom).

The red scaly skin of patients with psoriasis is caused by a complex circuit of inflammatory cells and cytokines. Zaba et al. (page 3183) now find that switching off one type of T helper (Th) cell is enough to break the circuit and heal the lesions.

Th1 cells that secrete interferon (IFN)-γ were initially thought to be the main villains within psoriatic plaques—build-ups of overproliferating skin cells. In animal models of psoriasis, IFN-γ thickens plaques by further increasing the proliferation of skin cells and enhancing their production of chemokines that recruit inflammatory cells.

But cytokines other than IFN-γ may be more to blame. Inhibitors of tumor necrosis factor (TNF)—originally given to patients to treat Crohn's disease and other inflammatory illnesses—have been shown to alleviate...

The Rockefeller University Press
2007
The Rockefeller University Press
2007
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