An injured heart remains scarred and deformed (right) when it is unable to recruit a clean-up crew of inflammatory monocytes.

It takes two to heal a wounded heart. Nahrendorf et al. (page 3037) now find that two sets of monocytes are involved in the healing: one type mops up injury debris and the other then helps repair the damage.

Circulating monocytes recruited to an injured heart break down dead cells and scoop up their toxic products. This inflammation is followed by reconstruction, when monocyte cytokines promote blood vessel growth and recruit healing fibroblasts.

Previous studies suggested that a single monocyte population accomplishes both these functions by switching from clean-up mode to repair mode. But the recent identification of two monocyte subsets in the circulation, only one of which is inflammatory, implies otherwise. Each subset has its own unique receptors that respond to different chemokine...

The Rockefeller University Press
2007
The Rockefeller University Press
2007
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