When cellular energy is in short supply—due, for example, to nutrient deficiency or metabolic stress—rising levels of AMP and falling levels of ATP trigger the activation of AMPK. AMPK then activates ATP-generating pathways, such as fatty acid oxidation. Tamás and colleagues now show that this pathway is also activated in T cells when their energy reserves dwindle. This is the first demonstration of physiological AMPK regulation in T cells.
But T cells turned on AMPK not...
The Rockefeller University Press
2006
The Rockefeller University Press
2006
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