We have examined whether psoriasis is associated with systemic effects on epidermal Langerhans cell (LC) function and, specifically, the migration of LCs from the skin. Compared with normal skin, the frequency and morphology of epidermal LCs in uninvolved skin from patients with psoriasis was normal. However, mobilization of these cells in response to stimuli that normally induce migration (chemical allergen, tumor necrosis factor α [TNF-α], and interleukin-1β [IL-1β]) was largely absent, despite the fact that treatment with TNF-α and IL-1β was associated with comparable inflammatory reactions in patients and controls. The failure of LC migration from uninvolved skin was not attributable to altered expression of receptors for IL-1β or TNF-α that are required for mobilization, nor was there an association with induced cutaneous cytokine expression. Although a role for altered dynamics of LC migration/turnover has not been formally excluded, these data reveal a very consistent decrement of LC function in psoriasis that may play a decisive role in disease pathogenesis.
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17 April 2006
Article|
March 27 2006
Impaired Langerhans cell migration in psoriasis
Marie Cumberbatch,
Marie Cumberbatch
1Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
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Minal Singh,
Minal Singh
2The Dermatology Centre, University of Manchester, Salford, Manchester, M6 8HD, England, UK
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Rebecca J. Dearman,
Rebecca J. Dearman
1Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
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Helen S. Young,
Helen S. Young
2The Dermatology Centre, University of Manchester, Salford, Manchester, M6 8HD, England, UK
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Ian Kimber,
Ian Kimber
1Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
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Christopher E.M. Griffiths
Christopher E.M. Griffiths
2The Dermatology Centre, University of Manchester, Salford, Manchester, M6 8HD, England, UK
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Marie Cumberbatch
1Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
Minal Singh
2The Dermatology Centre, University of Manchester, Salford, Manchester, M6 8HD, England, UK
Rebecca J. Dearman
1Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
Helen S. Young
2The Dermatology Centre, University of Manchester, Salford, Manchester, M6 8HD, England, UK
Ian Kimber
1Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
Christopher E.M. Griffiths
2The Dermatology Centre, University of Manchester, Salford, Manchester, M6 8HD, England, UK
CORRESPONDENCE Christopher E.M. Griffiths: [email protected]
Abbreviations used: LC, Langerhans cell; DPC, diphenylcyclopropenone; IL-1Ra, IL-1R antagonist; PDC, plasmacytoid DC.
Received:
November 28 2005
Accepted:
February 26 2006
Online ISSN: 1540-9538
Print ISSN: 0022-1007
The Rockefeller University Press
2006
J Exp Med (2006) 203 (4): 953–960.
Article history
Received:
November 28 2005
Accepted:
February 26 2006
Citation
Marie Cumberbatch, Minal Singh, Rebecca J. Dearman, Helen S. Young, Ian Kimber, Christopher E.M. Griffiths; Impaired Langerhans cell migration in psoriasis . J Exp Med 17 April 2006; 203 (4): 953–960. doi: https://doi.org/10.1084/jem.20052367
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