Intestinal inflammation is reduced by anti-p19 treatment (bottom).
IL-12, an activator of adaptive immunity via the induction of Th1 cells, is composed of two subunits, p35 and p40. In mouse models of intestinal inflammation, antibodies against p40 prevent the chronic inflammation that occurs in IBD in response to intestinal bacteria. Thus, IL-12 was considered responsible for driving IBD.
Case closed? Not quite. In 2000, it was discovered that p40 can also dimerize with p19 to form IL-23. Thus, all studies using antibodies against p40, including...
The Rockefeller University Press
2006
The Rockefeller University Press
2006
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