SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors

Veillette , André

doi:10.1084/jem.20040588

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Commentary| May 03 2004

SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors

André Veillette

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada H2W 1R7

Department of Microbiology and Immunology and Department of Medicine, McGill University, Montréal, Québec, Canada H3G 1Y6

Department of Medicine, University of Montréal, Montréal, Québec, Canada H3C 3J7

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Author and Article Information

André Veillette

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada H2W 1R7

Department of Microbiology and Immunology and Department of Medicine, McGill University, Montréal, Québec, Canada H3G 1Y6

Department of Medicine, University of Montréal, Montréal, Québec, Canada H3C 3J7

Address correspondence to André Veillette, IRCM, 110 Pine Ave. West, Montreal, Quebec, Canada H2W 1R7. Phone: (514) 987-5561; Fax: (514) 987-5562; email: [email protected]

Received: March 25 2004

Accepted: April 05 2004

Online ISSN: 1540-9538

Print ISSN: 0022-1007

The Rockefeller University Press

2004

J Exp Med (2004) 199 (9): 1175–1178.

https://doi.org/10.1084/jem.20040588

Two papers describing mice deficient in signaling lymphocyte activation molecule and 2B4 represent the first accounts of immune phenotypes in animals lacking members of the SLAM family of receptors. The findings provide definitive evidence of the importance of SLAM-related receptors in the regulation of T cell, macrophage, and natural killer cell functions.

The Rockefeller University Press

2004

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