It is well established that cancer is a progressive disease, occurring in a series of well-defined steps, typically arising as a consequence of activating mutations (oncogenes) or deactivating mutations (tumor suppressor genes) in proliferating cells. From studies exploiting cultured tumor cells, two-stage carcinogenesis protocols in mice, and transgenic models of tumorigenesis, it is now evident that a single mutagenic event does not result in formation of a malignant tumor 1. Additional genetic and epigenetic events are necessary for progression to the tumor state. Initiated cells therefore require alterations rendering them self-sufficient for growth, insensitive to growth-inhibitory signals, resistant to programs of terminal differentiation, senescence, or apoptosis, as well as endowing them with unlimited self-renewal capacity, the ability to orchestrate and direct sustained angiogenesis, and the ability to invade and thrive in ectopic tissue environments 1. In this...
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19 March 2001
Commentary|
March 19 2001
Inflammatory Cells and Cancer: Think Different!
Lisa M. Coussens,
Lisa M. Coussens
aCancer Research Institute, University of California, San Francisco, California 94143
bDepartment of Pathology, University of California, San Francisco, California 94143
dUniversity of California San Francisco Comprehensive Cancer Center, University of California, San Francisco, California 94143
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Zena Werb
Zena Werb
cDepartment of Anatomy, University of California, San Francisco, California 94143
dUniversity of California San Francisco Comprehensive Cancer Center, University of California, San Francisco, California 94143
Search for other works by this author on:
Lisa M. Coussens
aCancer Research Institute, University of California, San Francisco, California 94143
bDepartment of Pathology, University of California, San Francisco, California 94143
dUniversity of California San Francisco Comprehensive Cancer Center, University of California, San Francisco, California 94143
Zena Werb
cDepartment of Anatomy, University of California, San Francisco, California 94143
dUniversity of California San Francisco Comprehensive Cancer Center, University of California, San Francisco, California 94143
Received:
February 14 2001
Accepted:
February 16 2001
Online ISSN: 1540-9538
Print ISSN: 0022-1007
© 2001 The Rockefeller University Press
2001
The Rockefeller University Press
J Exp Med (2001) 193 (6): F23–F26.
Article history
Received:
February 14 2001
Accepted:
February 16 2001
Citation
Lisa M. Coussens, Zena Werb; Inflammatory Cells and Cancer: Think Different!. J Exp Med 19 March 2001; 193 (6): F23–F26. doi: https://doi.org/10.1084/jem.193.6.F23
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