The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune homeostasis. The immune system's ability to distinguish between self and non-self and between innocuous and harmful foreign antigens is controlled by mechanisms of central and peripheral tolerance. Central tolerance is a well established mechanism that involves deletion of self-reactive T cells upon interaction with bone marrow–derived dendritic cells (DCs) in the thymus 1,2. Well characterized mechanisms of peripheral tolerance include the induction of cell death or the development of a state of nonresponsiveness (anergy) of T cells 3,4. In addition, active suppression by T regulatory (Tr) cells is also key for peripheral tolerance 5. However, the mechanisms by which Tr cells arise in vivo and exert their immunoregulatory effects remain to be defined and are the...
Skip Nav Destination
Article navigation
15 January 2001
Commentary|
January 16 2001
Differentiation of T Regulatory Cells by Immature Dendritic Cells
Maria-Grazia Roncarolo,
Maria-Grazia Roncarolo
aSan Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), H.S. Raffaele Scientific Institute, 20132 Milan, Italy
Search for other works by this author on:
Megan K. Levings,
Megan K. Levings
aSan Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), H.S. Raffaele Scientific Institute, 20132 Milan, Italy
Search for other works by this author on:
Catia Traversari
Catia Traversari
bCancer Immunotherapy and Gene Therapy Program, H.S. Raffaele Scientific Institute, 20132 Milan, Italy
Search for other works by this author on:
Maria-Grazia Roncarolo
aSan Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), H.S. Raffaele Scientific Institute, 20132 Milan, Italy
Megan K. Levings
aSan Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), H.S. Raffaele Scientific Institute, 20132 Milan, Italy
Catia Traversari
bCancer Immunotherapy and Gene Therapy Program, H.S. Raffaele Scientific Institute, 20132 Milan, Italy
Received:
November 27 2000
Accepted:
December 05 2000
Online ISSN: 1540-9538
Print ISSN: 0022-1007
© 2001 The Rockefeller University Press
2001
The Rockefeller University Press
J Exp Med (2001) 193 (2): F5–F10.
Article history
Received:
November 27 2000
Accepted:
December 05 2000
Citation
Maria-Grazia Roncarolo, Megan K. Levings, Catia Traversari; Differentiation of T Regulatory Cells by Immature Dendritic Cells. J Exp Med 15 January 2001; 193 (2): F5–F10. doi: https://doi.org/10.1084/jem.193.2.F5
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionSuggested Content
Email alerts
Advertisement