Dendritic cells (DCs) express several receptors for the Fc portion of immunoglobulin (Ig)G (FcγR), which mediate internalization of antigen–IgG complexes (immune complexes, ICs) and promote efficient major histocompatibility complex (MHC) class II–restricted antigen presentation. We now show that FcγRs have two additional specific attributes in murine DCs: the induction of DC maturation and the promotion of efficient MHC class I–restricted presentation of peptides from exogenous, IgG-complexed antigens. Both FcγR functions require the FcγR-associated γ chain. FcγR-mediated MHC class I–restricted antigen presentation is extremely sensitive and specific to immature DCs. It requires proteasomal degradation and is dependent on functional peptide transporter associated with antigen processing, TAP1-TAP2. By promoting DC maturation and presentation on both MHC class I and II molecules, ICs should efficiently sensitize DCs for priming of both CD4+ helper and CD8+ cytotoxic T lymphocytes in vivo.
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18 January 1999
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January 18 1999
Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization
Armelle Regnault,
Armelle Regnault
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Danielle Lankar,
Danielle Lankar
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Valérie Lacabanne,
Valérie Lacabanne
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Ana Rodriguez,
Ana Rodriguez
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Clotilde Théry,
Clotilde Théry
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Maria Rescigno,
Maria Rescigno
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Takashi Saito,
Takashi Saito
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Sjef Verbeek,
Sjef Verbeek
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Christian Bonnerot,
Christian Bonnerot
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Paola Ricciardi-Castagnoli,
Paola Ricciardi-Castagnoli
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Sebastian Amigorena
Sebastian Amigorena
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
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Armelle Regnault
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Danielle Lankar
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Valérie Lacabanne
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Ana Rodriguez
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Clotilde Théry
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Maria Rescigno
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Takashi Saito
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Sjef Verbeek
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Christian Bonnerot
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Paola Ricciardi-Castagnoli
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Sebastian Amigorena
From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Address correspondence to Sebastian Amigorena, Institut Curie, 12 rue Lhomond, 75005 Paris, France. Phone: 33-1-42-34-63-89; Fax: 33-1-42-34-63-82; E-mail: [email protected]
Received:
August 06 1998
Revision Received:
October 21 1998
Online ISSN: 1540-9538
Print ISSN: 0022-1007
1999
J Exp Med (1999) 189 (2): 371–380.
Article history
Received:
August 06 1998
Revision Received:
October 21 1998
Citation
Armelle Regnault, Danielle Lankar, Valérie Lacabanne, Ana Rodriguez, Clotilde Théry, Maria Rescigno, Takashi Saito, Sjef Verbeek, Christian Bonnerot, Paola Ricciardi-Castagnoli, Sebastian Amigorena; Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization . J Exp Med 18 January 1999; 189 (2): 371–380. doi: https://doi.org/10.1084/jem.189.2.371
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