It is widely accepted that immunoglobulin (Ig)E triggers immediate hypersensitivity responses by activating a cognate high-affinity receptor, FcεRI, leading to mast cell degranulation with release of vasoactive and proinflammatory mediators. This apparent specificity, however, is complicated by the ability of IgE to bind with low affinity to Fc receptors for IgG, FcγRII and III. We have addressed the in vivo significance of this interaction by studying IgE-mediated passive systemic anaphylaxis in FcγR-deficient mice. Mice deficient in the inhibitory receptor for IgG, FcγRIIB, display enhanced IgE-mediated anaphylactic responses, whereas mice deficient in an IgG activation receptor, FcγRIII, display a corresponding attenuation of IgE-mediated responses. Thus, in addition to modulating IgG-triggered hypersensitivity responses, FcγRII and III on mast cells are potent regulators of IgE-mediated responses and reveal the existence of a regulatory pathway for IgE triggering of effector cells through IgG Fc receptors that could contribute to the etiology of the atopic response.
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17 May 1999
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May 17 1999
Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG
Azusa Ujike,
Azusa Ujike
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
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Yoko Ishikawa,
Yoko Ishikawa
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
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Masao Ono,
Masao Ono
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
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Takae Yuasa,
Takae Yuasa
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
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Tadashi Yoshino,
Tadashi Yoshino
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
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Manabu Fukumoto,
Manabu Fukumoto
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
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Jeffrey V. Ravetch,
Jeffrey V. Ravetch
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
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Toshiyuki Takai
Toshiyuki Takai
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
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Azusa Ujike
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
Yoko Ishikawa
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
Masao Ono
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
Takae Yuasa
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
Tadashi Yoshino
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
Manabu Fukumoto
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
Jeffrey V. Ravetch
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
Toshiyuki Takai
From the *Department of Experimental Immunology and the ‡Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; §Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; ‖Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and ¶Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021
Address correspondence to Toshiyuki Takai, Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo, Sendai 980-8575, Japan. Phone: 81-22-717-8501; Fax: 81-22-717-8505; E-mail: [email protected]
Received:
January 25 1999
Revision Received:
March 05 1999
Online ISSN: 1540-9538
Print ISSN: 0022-1007
1999
J Exp Med (1999) 189 (10): 1573–1579.
Article history
Received:
January 25 1999
Revision Received:
March 05 1999
Citation
Azusa Ujike, Yoko Ishikawa, Masao Ono, Takae Yuasa, Tadashi Yoshino, Manabu Fukumoto, Jeffrey V. Ravetch, Toshiyuki Takai; Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG . J Exp Med 17 May 1999; 189 (10): 1573–1579. doi: https://doi.org/10.1084/jem.189.10.1573
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