Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. The addition of recombinant APRIL to various tumor cells stimulates their proliferation. Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth.
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21 September 1998
Brief Definitive Report|
September 21 1998
APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth
Michael Hahne,
Michael Hahne
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Takao Kataoka,
Takao Kataoka
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Michael Schröter,
Michael Schröter
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Kay Hofmann,
Kay Hofmann
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Martin Irmler,
Martin Irmler
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Jean-Luc Bodmer,
Jean-Luc Bodmer
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Pascal Schneider,
Pascal Schneider
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Tierry Bornand,
Tierry Bornand
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Nils Holler,
Nils Holler
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Lars E. French,
Lars E. French
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Bernard Sordat,
Bernard Sordat
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Donata Rimoldi,
Donata Rimoldi
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Jürg Tschopp
Jürg Tschopp
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
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Michael Hahne
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Takao Kataoka
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Michael Schröter
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Kay Hofmann
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Martin Irmler
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Jean-Luc Bodmer
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Pascal Schneider
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Tierry Bornand
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Nils Holler
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Lars E. French
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Bernard Sordat
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Donata Rimoldi
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Jürg Tschopp
From the *Institute of Biochemistry, the ‡Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland; the §Swiss Institute for Experimental Cancer Research, BIL Research Centre, CH-1066 Epalinges, Switzerland; and the ‖Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland
Address correspondence to Dr. Jürg Tschopp, Institute of Biochemistry, University of Lausanne, Ch. des Boveresses 155, CH-1066 Epalinges, Switzerland. Phone: 41-21-692-5738; Fax: 41-21-692-5705; E-mail: [email protected]
T. Kataoka, M. Schröter, K. Hofmann, and M. Irmler contributed equally to this work.
Received:
March 30 1998
Revision Received:
May 04 1998
Online ISSN: 1540-9538
Print ISSN: 0022-1007
1998
J Exp Med (1998) 188 (6): 1185–1190.
Article history
Received:
March 30 1998
Revision Received:
May 04 1998
Citation
Michael Hahne, Takao Kataoka, Michael Schröter, Kay Hofmann, Martin Irmler, Jean-Luc Bodmer, Pascal Schneider, Tierry Bornand, Nils Holler, Lars E. French, Bernard Sordat, Donata Rimoldi, Jürg Tschopp; APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth . J Exp Med 21 September 1998; 188 (6): 1185–1190. doi: https://doi.org/10.1084/jem.188.6.1185
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