The thymus plays a critical role in the maturation and production of T lymphocytes and is a target of infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7–14 d after infection, followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.
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1 June 1998
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June 01 1998
Early Regeneration of Thymic Progenitors in Rhesus Macaques Infected with Simian Immunodeficiency Virus
Joanna J. Wykrzykowska,
Joanna J. Wykrzykowska
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
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Michael Rosenzweig,
Michael Rosenzweig
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
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Ronald S. Veazey,
Ronald S. Veazey
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
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Meredith A. Simon,
Meredith A. Simon
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
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Katherine Halvorsen,
Katherine Halvorsen
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
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Ronald C. Desrosiers,
Ronald C. Desrosiers
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
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R. Paul Johnson,
R. Paul Johnson
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
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Andrew A. Lackner
Andrew A. Lackner
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
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Joanna J. Wykrzykowska
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
Michael Rosenzweig
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
Ronald S. Veazey
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
Meredith A. Simon
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
Katherine Halvorsen
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
Ronald C. Desrosiers
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
R. Paul Johnson
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
Andrew A. Lackner
From the *New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the ‡Department of Mathematics, Smith College, Northampton, Massachusetts 01063
Address correspondence to Andrew A. Lackner, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Dr., PO Box 9102, Southborough, MA 01772. Phone: 508-624-8018; Fax: 508-624-8181; E mail: [email protected]
Received:
December 10 1997
Revision Received:
March 11 1998
Online ISSN: 1540-9538
Print ISSN: 0022-1007
1998
J Exp Med (1998) 187 (11): 1767–1778.
Article history
Received:
December 10 1997
Revision Received:
March 11 1998
Citation
Joanna J. Wykrzykowska, Michael Rosenzweig, Ronald S. Veazey, Meredith A. Simon, Katherine Halvorsen, Ronald C. Desrosiers, R. Paul Johnson, Andrew A. Lackner; Early Regeneration of Thymic Progenitors in Rhesus Macaques Infected with Simian Immunodeficiency Virus . J Exp Med 1 June 1998; 187 (11): 1767–1778. doi: https://doi.org/10.1084/jem.187.11.1767
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