The recent observation that neutralization or genetic deletion of the T lymphocyte receptor CTLA-4 allows enhanced T cell reactivity offers new opportunities for immunotherapy against infectious agents. We used a neutralizing antibody to block CTLA-4 interaction with its ligands CD80 and CD86 during infection of mice with the nematode, Nippostrongylus brasiliensis. CTLA-4 blockade greatly enhanced and accelerated the T cell immune response to N. brasiliensis, resulting in a profound reduction in adult worm numbers and early termination of parasite egg production. The ability of CTLA-4 blockade to accelerate primary immune responses to a protective level during an acute infection indicates its potential as an immunotherapeutic tool for dealing with infectious agents.
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21 July 1997
Article|
July 21 1997
Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade
Kathy McCoy,
Kathy McCoy
From the Malaghan Institute for Medical Research, Wellington School of Medicine, Wellington, New Zealand
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Mali Camberis,
Mali Camberis
From the Malaghan Institute for Medical Research, Wellington School of Medicine, Wellington, New Zealand
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Graham Le Gros
Graham Le Gros
From the Malaghan Institute for Medical Research, Wellington School of Medicine, Wellington, New Zealand
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Kathy McCoy
From the Malaghan Institute for Medical Research, Wellington School of Medicine, Wellington, New Zealand
Mali Camberis
From the Malaghan Institute for Medical Research, Wellington School of Medicine, Wellington, New Zealand
Graham Le Gros
From the Malaghan Institute for Medical Research, Wellington School of Medicine, Wellington, New Zealand
Address correspondence to Dr. Graham Le Gros, Malaghan Institute of Medical Research, PO Box 7060, Wellington South, New Zealand. Phone: 64-4-389-5096, ext. 822; FAX: 64-4-389-5095; E-mail: [email protected]
1 Abbreviation used in this paper: Nb, Nippostrongylus brasiliensis.
Received:
March 31 1997
Revision Received:
May 12 1997
Online ISSN: 1540-9538
Print ISSN: 0022-1007
1997
J Exp Med (1997) 186 (2): 183–187.
Article history
Received:
March 31 1997
Revision Received:
May 12 1997
Citation
Kathy McCoy, Mali Camberis, Graham Le Gros; Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade. J Exp Med 21 July 1997; 186 (2): 183–187. doi: https://doi.org/10.1084/jem.186.2.183
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