CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood. We created a mutant version of CTLA4-Ig that could selectively bind CD80 and block CD28-CD80 interaction but leave CD28-CD86 binding intact. CD80 blockade prevented antigen-induced accumulation of eosinophils and lymphocytes in the lung of immunized mice, but did not block antigen induced systemic blood eosinophilia or IgE antibody production. No preferential expression of CD80 could be demonstrated on a population of lung APC consisting mainly of macrophages. These results indicate that CD80 costimulation is not necessary for the induction of Th2 immune responses but rather for the maintenance or amplification of lung inflammatory responses.
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6 January 1997
Brief Definitive Report|
January 01 1997
CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
Nicola Harris,
Nicola Harris
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
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Robert Peach,
Robert Peach
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
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Joe Naemura,
Joe Naemura
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
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Peter S. Linsley,
Peter S. Linsley
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
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Graham Le Gros,
Graham Le Gros
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
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Franca Ronchese
Franca Ronchese
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
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Nicola Harris
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
Robert Peach
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
Joe Naemura
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
Peter S. Linsley
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
Graham Le Gros
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
Franca Ronchese
From the *Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand; and ‡Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
Address correspondence to Dr. Franca Ronchese, Malaghan Institute of Medical Research, PO Box 7060, Wellington South, New Zealand.
This work was supported by Grants from the Wellington Medical Research Foundation, the New Zealand Lottery Board, the Wellcome Trust and the Health Research Council of New Zealand. N. Harris is recipient of an Otago University Ph.D. Scholarship. G. Le Gros is a recipient of a Wellcome Trust Senior Research Fellowship.
The first two authors contributed equally to this work.
Received:
October 01 1996
Online ISSN: 1540-9538
Print ISSN: 0022-1007
1997
J Exp Med (1997) 185 (1): 177–182.
Article history
Received:
October 01 1996
Citation
Nicola Harris, Robert Peach, Joe Naemura, Peter S. Linsley, Graham Le Gros, Franca Ronchese; CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia. J Exp Med 6 January 1997; 185 (1): 177–182. doi: https://doi.org/10.1084/jem.185.1.177
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