Bordetella pertussis, the causative agent of whooping cough, adheres to human monocytes/macrophages by means of a bacterial surface-associated protein, filamentous hemagglutinin (FHA) and the leukocyte integrin, complement receptor 3 (CR3, alpha M beta 2, CD11b/CD18). We show that an FHA Arg-Gly-Asp site induces enhanced B. pertussis binding to monocytes, and that this enhancement is blocked by antibodies directed against CR3. Enhancement requires a monocyte signal transduction complex, composed of leukocyte response integrin (alpha? beta 3) and integrin-associated protein (CD47). This complex is known to upregulate CR3 binding activity. Thus, a bacterial pathogen enhances its own attachment to host cells by coopting a host cell signaling pathway.
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1 October 1994
Article|
October 01 1994
Bordetella pertussis filamentous hemagglutinin interacts with a leukocyte signal transduction complex and stimulates bacterial adherence to monocyte CR3 (CD11b/CD18).
Y Ishibashi,
Y Ishibashi
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
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S Claus,
S Claus
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
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D A Relman
D A Relman
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
Search for other works by this author on:
Y Ishibashi
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
S Claus
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
D A Relman
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1994) 180 (4): 1225–1233.
Citation
Y Ishibashi, S Claus, D A Relman; Bordetella pertussis filamentous hemagglutinin interacts with a leukocyte signal transduction complex and stimulates bacterial adherence to monocyte CR3 (CD11b/CD18).. J Exp Med 1 October 1994; 180 (4): 1225–1233. doi: https://doi.org/10.1084/jem.180.4.1225
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