In this report we show that passive immunization of Lewis rats with viable CD4+, Borna disease virus (BDV)-specific T cells before infection with BDV resulted in protection against BD, whereas inoculation of these T cells after BDV infection induced clinical disease with more rapid onset than seen in BDV control animals. The protective as well as encephalitogenic effector functions of BDV-specific CD4+ T cells were mediated only by viable BDV-specific T cells. The protective situation was obtained by passive transfer of BDV-specific T cells into animals inoculated later with virus, whereas the immunopathological situation was observed when virus-specific T cells developed normally or after adoptive transfer, and appeared on the scene after considerable virus replication in the brain.
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1 May 1994
Article|
May 01 1994
Borna disease virus-specific T cells protect against or cause immunopathological Borna disease.
J A Richt,
J A Richt
Institut für Virologie, Giessen, Germany.
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A Schmeel,
A Schmeel
Institut für Virologie, Giessen, Germany.
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K Frese,
K Frese
Institut für Virologie, Giessen, Germany.
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K M Carbone,
K M Carbone
Institut für Virologie, Giessen, Germany.
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O Narayan,
O Narayan
Institut für Virologie, Giessen, Germany.
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R Rott
R Rott
Institut für Virologie, Giessen, Germany.
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J A Richt
Institut für Virologie, Giessen, Germany.
A Schmeel
Institut für Virologie, Giessen, Germany.
K Frese
Institut für Virologie, Giessen, Germany.
K M Carbone
Institut für Virologie, Giessen, Germany.
O Narayan
Institut für Virologie, Giessen, Germany.
R Rott
Institut für Virologie, Giessen, Germany.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1994) 179 (5): 1467–1473.
Citation
J A Richt, A Schmeel, K Frese, K M Carbone, O Narayan, R Rott; Borna disease virus-specific T cells protect against or cause immunopathological Borna disease.. J Exp Med 1 May 1994; 179 (5): 1467–1473. doi: https://doi.org/10.1084/jem.179.5.1467
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