Transgenic mice expressing either the mouse mammary tumor virus (MMTV) superantigen gene (sag) alone or in combination with the viral envelope genes (env) (LEL), or all of the viral genes (gag, pol, env, and sag) (HYB PRO), deleted V beta 14+ T cells from their immune repertoire. However, only LEL or HYB PRO transgenic antigen-presenting cells were capable of stimulating a proliferative response from nontransgenic primary T cells or interleukin 2 production from a V beta 15-bearing T cell hybridoma. These T cell responses could be inhibited by a monospecific antibody directed against the MMTV gp52 cell surface glycoprotein. These results indicate that the MMTV gp52 gene product participates in the presentation of superantigen to T cells, resulting in their stimulation, a requisite step in the MMTV infection pathway. Thus, gp52 could play a role in the transfer of virus between different subsets of lymphocytes.
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1 February 1994
Article|
February 01 1994
The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells.
T V Golovkina,
T V Golovkina
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
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A Chervonsky,
A Chervonsky
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
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J A Prescott,
J A Prescott
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
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C A Janeway, Jr,
C A Janeway, Jr
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
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S R Ross
S R Ross
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
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T V Golovkina
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
A Chervonsky
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
J A Prescott
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
C A Janeway, Jr
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
S R Ross
Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1994) 179 (2): 439–446.
Citation
T V Golovkina, A Chervonsky, J A Prescott, C A Janeway, S R Ross; The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells.. J Exp Med 1 February 1994; 179 (2): 439–446. doi: https://doi.org/10.1084/jem.179.2.439
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