The B7-1 molecule, expressed on antigen presenting cells (APC), provides a crucial costimulatory signal for T cell activation. Recent studies demonstrate the existence of alternative, non-B7-1 CTLA4 counter-receptors in mice and humans. Here, we describe the molecular cloning and demonstrate costimulatory function of the murine B7-2 (mB7-2) gene. Murine B7-2 cDNA encodes a member of the Ig supergene family that binds CTLA4-Ig and stains with the GL1 but not anti-mB7-1 mAb. Murine B7-2 costimulates the proliferation and interleukin 2 production of CD4+ T cells and this costimulation can be inhibited by either CTLA4-Ig or GL1 mAb. Identification of the B7-2 molecule will permit further manipulation of the B7:CD28/CTLA4 costimulatory pathway which has been shown to be involved in the prevention of tolerance, induction of tumor immunity, and most recently, in the pathogenesis of autoimmunity.
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1 December 1993
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December 01 1993
Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.
G J Freeman,
G J Freeman
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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F Borriello,
F Borriello
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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R J Hodes,
R J Hodes
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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H Reiser,
H Reiser
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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J G Gribben,
J G Gribben
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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J W Ng,
J W Ng
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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J Kim,
J Kim
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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J M Goldberg,
J M Goldberg
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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K Hathcock,
K Hathcock
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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G Laszlo
G Laszlo
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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G J Freeman
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
F Borriello
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
R J Hodes
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
H Reiser
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
J G Gribben
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
J W Ng
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
J Kim
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
J M Goldberg
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
K Hathcock
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
G Laszlo
Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1993) 178 (6): 2185–2192.
Citation
G J Freeman, F Borriello, R J Hodes, H Reiser, J G Gribben, J W Ng, J Kim, J M Goldberg, K Hathcock, G Laszlo; Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.. J Exp Med 1 December 1993; 178 (6): 2185–2192. doi: https://doi.org/10.1084/jem.178.6.2185
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