Intravenous infusion of mice with major histocompatibility complex (MHC) incompatible lymphocytes can inhibit the response of recipient T cells capable of recognizing the injected cells, and can enhance survival of grafts sharing MHC with the injected cells. However, neither T cell inactivation nor graft survival enhancement is always achieved. This is particularly true for donor cells that are fully allogeneic (as compared to semiallogeneic) to the recipient. We show here that both donor-specific induced response reduction and graft survival enhancement are directly correlated with the ability of the injected lymphoid cells to persist in the recirculating lymphocyte pool of the host. Whether donor cells persist correlates inversely with the level of natural killer cell (NK) activity in the host. Fully allogeneic cells can only persist in hosts with low NK activity and can then induce response reduction. Both persistence and response reduction are abrogated by injection of the host with poly-I:C, a treatment that boosts host NK activity. The same treatment also destroys the ability of semiallogeneic injected cells to persist, to induce response reduction, and to enhance skin graft survival.
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1 August 1992
Article|
August 01 1992
Correlation between lymphocyte-induced donor-specific tolerance and donor cell recirculation.
X Sheng-Tanner,
X Sheng-Tanner
Department of Immunology, University of Toronto, Canada.
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R G Miller
R G Miller
Department of Immunology, University of Toronto, Canada.
Search for other works by this author on:
X Sheng-Tanner
Department of Immunology, University of Toronto, Canada.
R G Miller
Department of Immunology, University of Toronto, Canada.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1992) 176 (2): 407–413.
Citation
X Sheng-Tanner, R G Miller; Correlation between lymphocyte-induced donor-specific tolerance and donor cell recirculation.. J Exp Med 1 August 1992; 176 (2): 407–413. doi: https://doi.org/10.1084/jem.176.2.407
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