The dominant trans-acting major histocompatibility complex (MHC)-linked class I modifier (cim) locus, previously recognized through its ability to determine altered alloantigenicity of a rat class I molecule, RT1.A3, is shown here to influence class I intracellular transport. The MHC recombinant laboratory rat strains PVG.R1 and PVG.R8 display unusually long retention of RT1.Aa within the endoplasmic reticulum or cis-Golgi. In appropriate F1 hybrid cells heterozygous for RT1.Aa and another class I MHC allele, RT1.Ac, only the RT1.Aa protein is subject to slow transport. The cim gene product therefore shows class I allele specificity in its action, cim appears to be a polymorphic locus whose product is directly involved in the processes of class I MHC assembly and/or intracellular transport.
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1 April 1991
Article|
April 01 1991
The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule.
S J Powis,
S J Powis
Department of Immunology, Agricultural & Food Research Council, Institute of Animal Physiology & Genetics Research, Cambridge Research Station, Babraham, UK.
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J C Howard,
J C Howard
Department of Immunology, Agricultural & Food Research Council, Institute of Animal Physiology & Genetics Research, Cambridge Research Station, Babraham, UK.
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G W Butcher
G W Butcher
Department of Immunology, Agricultural & Food Research Council, Institute of Animal Physiology & Genetics Research, Cambridge Research Station, Babraham, UK.
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S J Powis
Department of Immunology, Agricultural & Food Research Council, Institute of Animal Physiology & Genetics Research, Cambridge Research Station, Babraham, UK.
J C Howard
Department of Immunology, Agricultural & Food Research Council, Institute of Animal Physiology & Genetics Research, Cambridge Research Station, Babraham, UK.
G W Butcher
Department of Immunology, Agricultural & Food Research Council, Institute of Animal Physiology & Genetics Research, Cambridge Research Station, Babraham, UK.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1991) 173 (4): 913–921.
Citation
S J Powis, J C Howard, G W Butcher; The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule.. J Exp Med 1 April 1991; 173 (4): 913–921. doi: https://doi.org/10.1084/jem.173.4.913
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