Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.

Sollid, L M; Markussen, G; Ek, J; Gjerde, H; Vartdal, F; Thorsby, E

doi:10.1084/jem.169.1.345

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Article| January 01 1989

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.

L M Sollid,

L M Sollid

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

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G Markussen,

G Markussen

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

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J Ek,

J Ek

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

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H Gjerde,

H Gjerde

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

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F Vartdal,

F Vartdal

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

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E Thorsby

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

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Author and Article Information

L M Sollid

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

G Markussen

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

J Ek

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

H Gjerde

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

F Vartdal

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

E Thorsby

Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

Online ISSN: 1540-9538

Print ISSN: 0022-1007

J Exp Med (1989) 169 (1): 345–350.

https://doi.org/10.1084/jem.169.1.345

Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.

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Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.

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