EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT

Fu , S. M.; Kunkel , H. G.; Brusman , H. P.; Allen , F. H.; Fotino , M.

doi:10.1084/jem.140.4.1108

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Brief Definitive Report| October 01 1974

EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT

S. M. Fu,

S. M. Fu

From The Rockefeller University and the New York Blood Center, New York 10021

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H. G. Kunkel,

H. G. Kunkel

From The Rockefeller University and the New York Blood Center, New York 10021

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H. P. Brusman,

H. P. Brusman

From The Rockefeller University and the New York Blood Center, New York 10021

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F. H. Allen, Jr.,

F. H. Allen, Jr.

From The Rockefeller University and the New York Blood Center, New York 10021

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M. Fotino

From The Rockefeller University and the New York Blood Center, New York 10021

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Author and Article Information

S. M. Fu

From The Rockefeller University and the New York Blood Center, New York 10021

H. G. Kunkel

From The Rockefeller University and the New York Blood Center, New York 10021

H. P. Brusman

From The Rockefeller University and the New York Blood Center, New York 10021

F. H. Allen, Jr.

From The Rockefeller University and the New York Blood Center, New York 10021

M. Fotino

From The Rockefeller University and the New York Blood Center, New York 10021

Received: July 15 1974

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1974

J Exp Med (1974) 140 (4): 1108–1111.

https://doi.org/10.1084/jem.140.4.1108

HL-A analysis of a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci. The propositus was homozygous both for C2 deficiency and the HL-A haplotype 10,W18. Among seven children of three double backcross matings, no recombinants were found. The possible significance of such linkage is discussed.

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EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT

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