IN VIVO STUDIES IN C4-DEFICIENT GUINEA PIGS

Ellman , Leonard; Green , Ira; Judge , Francis; Frank , Michael M.

doi:10.1084/jem.134.1.162

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Article| July 01 1971

IN VIVO STUDIES IN C4-DEFICIENT GUINEA PIGS

Leonard Ellman,

Leonard Ellman

From the Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; and the Laboratory Aids Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014

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Ira Green,

Ira Green

From the Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; and the Laboratory Aids Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014

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Francis Judge,

Francis Judge

From the Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; and the Laboratory Aids Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014

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Michael M. Frank

From the Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; and the Laboratory Aids Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014

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Author and Article Information

Leonard Ellman

From the Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; and the Laboratory Aids Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014

Ira Green

From the Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; and the Laboratory Aids Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014

Francis Judge

From the Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; and the Laboratory Aids Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014

Michael M. Frank

From the Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; and the Laboratory Aids Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014

Received: March 01 1971

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1971

J Exp Med (1971) 134 (1): 162–175.

https://doi.org/10.1084/jem.134.1.162

Guinea pigs with a genetically determined total deficiency of the fourth component of complement have been studied for various in vivo immunological functions. Passive cutaneous anaphylaxsis, contact and delayed hypersensitivity, and the cellular exudative response to a foreign body were normal. These animals also have normal direct and reverse passive Arthus reactions which suggest that they possess a mechanism to bypass C4 and directly activate late-acting complement components. This would appear to be an unequivocal demonstration of an alternate pathway in the complement sequence. Immune clearance of guinea pig erythrocytes sensitized with rabbit antibody was impaired in the deficient animals. Antibody production in C4-deficient animals was impaired for two of the three antigens studied.

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