The pathogenesis of the spontaneous glomerulonephritis of NZB and (NZB x NZW) F1 hybrid mice is related at least in part to the formation of natural antibody against antigens of the G (Gross) system, and apparently to the deposition in the glomeruli of immune complexes of G natural antibody with G soluble antigen (GSA), type-specific antigen specified by wild-type Gross leukemia virus. G natural antibody and GSA are detectable in the acid-buffer eluate of the kidneys of NZB mice during the course of the glomerulonephritis. (NZB x NZW) F1 hybrid mice develop glomerulonephritis and produce GSA and free G natural antibody earlier in life than do NZB mice. The proteinuria manifestation of the gomerulonephritis of (NZB x NZW) F1 hybrid mice becomes increasingly prevalent as GSA undergoes immune elimination from the circulation. Gross leukemia virus-specified antigens together with bound immunoglobulins are located in the glomerular lesions of (NZB x NZW) F1 hybrid mice, both in the mesangium as observed in NZB mice and also in the wall of the peripheral capillary loops of the glomeruli.
Skip Nav Destination
Article navigation
1 January 1971
Article|
January 01 1971
WILD-TYPE GROSS LEUKEMIA VIRUS AND THE PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NEW ZEALAND MICE
Robert C. Mellors,
Robert C. Mellors
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Search for other works by this author on:
Toshikazu Shirai,
Toshikazu Shirai
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Search for other works by this author on:
Tadao Aoki,
Tadao Aoki
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Search for other works by this author on:
Robert J. Huebner,
Robert J. Huebner
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Search for other works by this author on:
Krzysztof Krawczynski
Krzysztof Krawczynski
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Search for other works by this author on:
Robert C. Mellors
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Toshikazu Shirai
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Tadao Aoki
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Robert J. Huebner
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Krzysztof Krawczynski
From The Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated with The New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, 10021, the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021, and the Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Received:
August 12 1970
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1971 by The Rockefeller University Press
1971
J Exp Med (1971) 133 (1): 113–132.
Article history
Received:
August 12 1970
Citation
Robert C. Mellors, Toshikazu Shirai, Tadao Aoki, Robert J. Huebner, Krzysztof Krawczynski; WILD-TYPE GROSS LEUKEMIA VIRUS AND THE PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NEW ZEALAND MICE . J Exp Med 1 January 1971; 133 (1): 113–132. doi: https://doi.org/10.1084/jem.133.1.113
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionSuggested Content
Email alerts
Advertisement
